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oral absorption

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Adrenergic Receptor (1) Antibiotic (7) Apoptosis (2) Bacterial (9) Beta-lactamase (1) Biochemical Assay Reagents (1) Btk (1) Carbonic Anhydrase (1) EGFR (1) Endogenous Metabolite (4) Epoxide Hydrolase (1) Glucosidase (1) GLUT (1) HIV (1) HIV Integrase (1) Isotope-Labeled Compounds (1) Microsomal Triglyceride Transfer Protein (MTP) (1) Na+/H+ Exchanger (NHE) (2) P-glycoprotein (1) p38 MAPK (2) Penicillin-binding protein (PBP) (1) PGC-1α (1) PKA (1) Potassium Channel (1) Pyroptosis (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Endocrinology (2) Infection (10) Inflammation/Immunology (1) Metabolic Disease (11) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0467S

Amoxicillin-d4 Amoxycillin d₄	Bacterial	Infection
Amoxicillin-d₄ is a deuterium labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity[1][2].

HY-157049

Caprylocaproyl Macrogolglycerides	Others	Others
Caprylocaproyl Macrogolglycerides is a lipoidic excipient/vehicle in an oral capsule formulation. Caprylocaproyl Macrogolglycerides can enhance the absorption of small molecule compounds .

HY-15991

Tenapanor 4 Publications Verification AZD1722; RDX5791	Na+/H+ Exchanger (NHE)	Metabolic Disease
Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia .

HY-15991A

Tenapanor hydrochloride 4 Publications Verification AZD1722 hydrochloride; RDX5791 hydrochloride	Na+/H+ Exchanger (NHE)	Metabolic Disease
Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia .

HY-150752

BTK-IN-15	Btk Pyroptosis	Cancer
BTK-IN-15 (compound 42) is a potent Bruton's tyrosine kinase (BTK) inhibitor with high *oral* absorption. BTK-IN-15 inhibits BTK with an IC₅₀ value of 0.7 nM. BTK-IN-15 displays excellent kinase selectivity, antitumor activity, and induces apoptosis .

HY-147826

EGFR-IN-60	EGFR Apoptosis	Cancer
EGFR-IN-60 (Compound 7d) shows obvious inhibition of EGFR ^WT, EGFR ^T790M, EGFR ^L858R and JAK3 with IC₅₀s of 83, 26, 53, and 69 nM, respectively. EGFR-IN-60 potently inhibits the growth of H1975 cells harboring EGFR ^T790M mutation (IC₅₀=1.32 µM) over A431 cells overexpressing EGFR ^WT (IC₅₀=4.96 µM). EGFR-IN-60 exhibits good oral absorption, potent and safe antitumor activity. EGFR-IN-60 induces cell death through apoptosis supported by increased Bax/Bcl-2 ratio .

HY-B0467AS

Amoxicillin-13C6 Amoxycillin-¹³C₆	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Amoxicillin- ¹³C₆ is the ¹³C₆ labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity.

HY-N0324

Cholic acid 4 Publications Verification	Endogenous Metabolite	Metabolic Disease
Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

HY-N0324A

Cholic acid sodium 4 Publications Verification Sodium cholate
Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active .

HY-N0324B

Cholic acid sodium hydrate	Endogenous Metabolite	Metabolic Disease
Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active .

HY-B0467

Amoxicillin sodium Maximum Cited Publications 13 Publications Verification Amoxycillin sodium	Bacterial Antibiotic	Infection
Amoxicillin (Amoxycillin) sodium is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin sodium inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .

HY-B0467A

Amoxicillin Maximum Cited Publications 13 Publications Verification Amoxycillin	Bacterial Antibiotic	Infection Cancer
Amoxicillin (Amoxycillin) is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .

HY-B0544

Sodium Picosulfate Sodium Picosulphate	Others	Metabolic Disease
Sodium Picosulfate (Sodium Picosulphate) is a contact irritant laxative with oral activity. Sodium Picosulfate inhibits the absorption of water and electrolytes, increasing their production. Sodium Picosulfate can be used in colonoscopy applications .

HY-114299

Salcaprozate sodium SNAC	Others	Others
Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .

HY-B0467B

Amoxicillin trihydrate Maximum Cited Publications 13 Publications Verification Amoxycillin trihydrate	Bacterial Antibiotic	Infection
Amoxicillin (Amoxycillin) trihydrateis an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin trihydrateis inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .

HY-B0467C

Amoxicillin arginine Amoxycillin arginine	Antibiotic Bacterial	Infection
Amoxicillin (Amoxycillin) arginine is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin arginine inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .

HY-106902

F-1394	Acyltransferase	Cardiovascular Disease
F-1394 is an orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor that inhibits dietary cholesterol absorption in mice. F-1394 can be used in cardiovascular disease research .

HY-109519

Simethicone	Others	Others
Simethicone is an orally active defoamer. Simethicone reduces the surface tension of air bubbles in the gastrointestinal tract, causing them to be expelled by vomiting, exhalation or absorption into the bloodstream. Simethicone has potential applications in flatulence and colic .

HY-119220

Granotapide JTT-130	Microsomal Triglyceride Transfer Protein (MTP)	Metabolic Disease
Granotapide (JTT-130) is an orally active microsomal triglyceride transfer protein (MTP) inhibitor. Granotapide reduces absorption of cholesterol and triglycerides through inhibition of MTP. Granotapide can be used for the research of dyslipidemia .

HY-N3197

Neostenine (+)-Neostenine	P-glycoprotein	Cancer
Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application .

HY-113478

3β-Ursodeoxycholic acid Isoursodeoxycholic acid	Others	Metabolic Disease
3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA .

HY-N0324R

Cholic acid (Standard)	Endogenous Metabolite	Metabolic Disease
Cholic acid (Standard) is the analytical standard of Cholic acid. This product is intended for research and analytical applications. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

HY-108288

Sulbactam pivoxil CP 47904	Beta-lactamase Antibiotic Bacterial	Infection
Sulbactam pivoxil is a proagent of sulbactam. Sulbactam is a β-lactamase inhibitor which poorly adsorbed from gastrointestinal tract. Sulbactam pivoxil has a better absorption than the parent agent and provides high serum levels after oral administration .

HY-131165

Amoxicillin trihydrate mixture with potassium clavulanate (4:1)	Antibiotic Bacterial	Infection
Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .

HY-122487

Troriluzole BHV-4157	Others	Neurological Disease
Troriluzole, a third-generation, tripeptide proagent of Riluzole (HY-B0211), is an orally active glutamate modulator. Troriluzole reduces synaptic glutamate level and increases the synaptic glutamate absorption. Troriluzole has the potential for Alzheimer disease and generalized anxiety disorder (GAD) .

HY-100500

Lenampicillin hydrochloride KBT 1585 hydrochloride	Penicillin-binding protein (PBP) Bacterial	Cancer
Lenampicillin hydrochloride (KBT 1585 hydrochloride) is an orally active proagent of Ampicillin and is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins (transpeptidase). Lenampicillin hydrochloride has improved absorption and decreased side effects compares to Ampicillin and is applied in the investigation of the suppurative skin and soft tissue infection .

HY-150555

P-CAB agent 1	Potassium Channel	Others
P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC₅₀ value of 60.50 nM for H ⁺/K ⁺-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs) .

HY-113133

Kojibiose	Glucosidase	Infection Metabolic Disease Inflammation/Immunology
Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo .

HY-B0558

Carbimazole	p38 MAPK	Neurological Disease Endocrinology
Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research .

HY-163380

CA/MAO-B-IN-1	Carbonic Anhydrase	Neurological Disease
CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC₅₀s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 reveals a human oral absorption of 71.9% through in silico prediction .

HY-143294

sEH inhibitor-2	Epoxide Hydrolase	Cardiovascular Disease
sEH inhibitor-2 (compound 5l) is an orally active (predicted percentage absorption: 71.2-88.4%) soluble epoxide hydrolase (sEH) inhibitor, with an IC₅₀ of 0.9 nM. sEH inhibitor-2 can maintain epoxyeicosatrienoic acids (EETs) serum level in high concentrations. sEH inhibitor-2 can be used in study of cardiovascular protection .

HY-150080

GSK3739936 BMS-986180	HIV HIV Integrase	Infection
GSK3739936 (BMS-986180) is a potent HIV-1 allosteric integrase inhibitor with an IC₅₀ value of 11.1 nM and an EC₅₀ value of 1.7 nM. GSK3739936 is also a weak CYP inhibitor (IC₅₀>24.3 μM). GSK3739936 shows favorable pharmacokinetic property in preclinical species with rapid absorption, low to moderate clearance and excellent oral bioavailability .

HY-B0558R

Carbimazole (Standard)	p38 MAPK	Neurological Disease Endocrinology
Carbimazole (Standard) is the analytical standard of Carbimazole. This product is intended for research and analytical applications. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research .

HY-149276

SLC26A3-IN-2	GLUT	Metabolic Disease
SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC₅₀=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea .

HY-W115716

Sorbitan trioleate	Biochemical Assay Reagents	Others
Sorbitan trioleate is an orally active nonionic surfactant with low toxicity (LD≥200 mg/kg). Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

HY-N0378

D-Mannitol 4 Publications Verification Mannitol; Mannite	Endogenous Metabolite Apoptosis Adrenergic Receptor PGC-1α PKA	Metabolic Disease Cancer
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells .

Molecular Glue Compound Library	35 Compounds compounds
Targeted protein degradation(TPD) is a novel and promising approach to new drug discovery and development. It shows great potential for treating diseases with “undruggable” pathogenic protein targets and for overcoming drug resistance. Molecular glues and PROTACs are both targeted protein degraders that have attracted the most attention. Molecular glues are small molecular degraders that mainly induce novel interaction between an E3 ligase and a target protein to form a ternary complex, leading to protein ubiquitination and subsequent proteasome degradation. Compared with PROTACs, molecular glues generally possess more favorable drug-like properties, such as lower MW, higher cell permeability, and better oral absorption. Molecular glues are emerging as a promising new therapeutic strategy. MCE supplies a unique collection of 35 molecular glues which target various proteins. MCE Molecular Glue Compound Library is a useful tool to conduct scientific research and disease mechanism study.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0324

Cholic acid 4 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other disease Source classification Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

HY-N0378

D-Mannitol 4 Publications Verification Mannitol; Mannite	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields Sweeteners Food Research	Endogenous Metabolite Apoptosis Adrenergic Receptor PGC-1α PKA
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells .

HY-N0324B

Cholic acid sodium hydrate	Source classification Endogenous metabolite Steroids	Endogenous Metabolite
Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active .

HY-N3197

Neostenine (+)-Neostenine	Structural Classification Alkaloids Pyrrole Alkaloids Stemonaceae Other Alkaloids Source classification Plants Stemona sesslifolia	P-glycoprotein
Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application .

HY-N0324R

Cholic acid (Standard)	Structural Classification Classification of Application Fields Other disease Source classification Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholic acid (Standard) is the analytical standard of Cholic acid. This product is intended for research and analytical applications. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

Cat. No.	Product Name	Chemical Structure

HY-B0467S

Amoxicillin-d4

Amoxicillin-d₄ is a deuterium labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity[1][2].
HY-B0467AS

Amoxicillin-13C6

Amoxicillin- ¹³C₆ is the ¹³C₆ labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity.

Amoxicillin-d4
Amoxicillin-d₄ is a deuterium labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity[1][2].

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oral absorption

Inhibitors & Agonists

Screening Libraries

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
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